What is this medicine used for?
For documented multi-drug resistant Gram-negative infections due to organisms proven or suspected to be susceptible to Piperacillin/Tazobactam except CNS infections; and for polymicrobial infections (e.g., mixed aerobic and anaerobic infections in which other agents have insufficient activity or are contraindicated due to toxic potential).
How much and how often should you use this medicine?
Piperacillin/Tazobactam should be administered by intravenous infusion over 30 minutes.
Adults: The usual total daily dose of Piperacillin/Tazobactam is 3.375 g every six hours totaling 13.5 g (12.0 g Piperacillin/1.5 g Tazobactam). Initial presumptive treatment of patients with nosocomial pneumonia should start with (16.0 g Piperacillin/2.0 g Tazobactam). Treatment with aminoglycoside should be continued in patients from whom Pseudomonas aeruginosa is
isolated. If Pseudomonas aeruginosa is not isolated, the aminoglycoside may be discontinued at the discretion of the treating physician.
Pediatrics: Piperacillin/Tazobactam can be administered in pediatric patients from 2 months of age. The dosage and indications in pediatric patients with normal renal function are as follows: